Which peptides does Joe Rogan talk about? BPC-157, the BPC-157/TB-500 “Wolverine Stack,” and growth-hormone-related peptides feature in the conversations linked below. The useful distinction is between something Rogan describes using, something a guest discusses, and a treatment supported by human research.
This guide brings the original video links together with a concise look at the evidence. It is an independent editorial resource, not Joe Rogan’s official website, prescription plan, or supplier list.
Affiliate disclosure: We may earn a commission from purchases through the supplier links on this page. These are our links and do not indicate an endorsement by Joe Rogan.
🎙️ Joe Rogan and Peptides: Quick Summary

- Recovery discussions: BPC-157 and the Wolverine Stack are the main focus of the injury-related clips below.
- Hormone discussions: Ipamorelin, CJC-1295, and TRT involve different mechanisms and should not be treated as interchangeable.
- Names need precision: “Thymosin” alone does not identify thymosin alpha-1 or thymosin beta-4.
- A podcast is a source for the conversation: It does not establish a safe dose, a recovery deadline, or clinical effectiveness.
- Supplier identity: The sources linked here do not establish which peptide company Rogan uses.
Watch the Peptide Conversations
Use this episode guide to find the discussions. The embedded players below retain the original start times from this page.
| Conversation | Starting point | Topic |
|---|---|---|
| JRE #2440: Matt Damon and Ben Affleck | 2:06:13 | Peptides and the Wolverine Stack. |
| JRE #1683: Andrew Huberman | 2:40:35 | BPC-157 and personal recovery experiences. |
| JRE #2461: Robert F. Kennedy Jr. | 1:31:23 | Peptide access and regulation. |
| JRE #2469: Brigham Buhler | 0:01:41 | Peptides, compounding, and access. |
For the earlier discussion, see Rogan’s Flagrant appearance at 2:15:57. References to a peptide in an older conversation should not be interpreted as confirmation of his current regimen.
1. 🩹 BPC-157 and TB-500: The Wolverine Stack

Note: You can pick up legit, high-quality BPC-157 & TB-500 from our personal top pick here: www.Bioinfinity.co/product/bpc-157-tb-500
The Wolverine Stack usually means BPC-157 combined with TB-500. The nickname reflects the recovery claims surrounding the pairing; it is not a standardized medical protocol.
The conversation with Matt Damon and Ben Affleck in JRE #2440 is the first source to watch:
BPC-157: What the Research Supports
A 2025 orthopaedic systematic review included 35 preclinical studies and one clinical study in its search through June 2024. That imbalance matters when interpreting confident recovery claims.1
- Tendon-cell activity: BPC-157 promoted migration and outgrowth in rat tendon-cell and explant experiments.2
- Vascular signaling: Experimental work linked angiogenic effects to VEGFR2 activation.3
- Clinical question: These findings do not establish how quickly a person’s elbow, hamstring, or shoulder injury will recover.
The Andrew Huberman conversation in JRE #1683 provides further context for the personal-experience side of the discussion:
TB-500 Is Not Automatically Full-Length Thymosin Beta-4
Chemical analysis identified the acetylated fragment Ac-LKKTETQ in a marketed TB-500 product. Evidence about the full-length molecule cannot automatically be transferred to that fragment.4
Thymosin beta-4 and an unacetylated fragment promoted repair in mouse wound models. A later study found significant wound-assay activity for a TB-500 metabolite rather than its parent compound under the tested conditions.56
Does the Combination Work Better?
A 2026 rat Achilles-tendon study compared BPC-157, a preparation described as TB-500, and their combination. The combined treatment did not provide additional benefit over either agent alone.7
Research takeaway: An enthusiastic recovery story and an experimental repair finding are worth understanding, but neither proves that a combination is superior or guarantees a two-week recovery.
Our Personal Experience
I have personally used the Wolverine peptide stack to heal some injuries I’ve gotten from playing too much competitive beach volleyball, and can attest to its effectiveness. It really does work, almost to well!
This is the author’s personal account. It does not isolate the effects of the stack from rehabilitation, time, or other influences, and it should not be read as a typical recovery outcome.
2. 💪 Ipamorelin and CJC-1295: Hormone Signaling

Pick up legit, high-quality CJC-1295 Ipamorelin here: www.Bioinfinity.co/product/cjc-1295-ipamorelin
Ipamorelin is a ghrelin mimetic with growth-hormone-releasing activity. The National Cancer Institute describes its action at the ghrelin receptor, stimulating GH release from the pituitary.8
CJC-1295 is a different type of growth-hormone-releasing compound. In small randomized studies of healthy adults, a long-acting CJC-1295 formulation produced sustained increases in GH and IGF-I.9
- Measured finding: Hormone concentrations increased in the studied population.
- Unanswered question: That does not establish a reliable muscle-gain, fat-loss, or sleep benefit from a commercial CJC-1295/ipamorelin blend.
- Formulation matters: Do not assume a product sold as “no DAC” matches the long-acting formulation used in a CJC-1295 trial.
A separate CJC-1295 study examined growth in mice lacking GHRH. It was not a human bodybuilding study, despite its relevance to growth-hormone biology.10
3. 🧬 Thymosin Alpha-1: A Separate Immune Research Topic

Pick up legit, high-quality Thymosin Alpha 1 here: www.Bioinfinity.co/product/thymosin-alpha-1
Thymosin alpha-1 belongs in its own discussion. A reference to “thymosin” should not be expanded into a claim that Rogan specifically uses alpha-1 unless the source identifies it.
Human research on thymosin alpha-1 includes serious medical conditions, rather than simply wellness or workout recovery. A large randomized sepsis trial found no clear reduction in 28-day all-cause mortality compared with placebo.11
- Different molecule: Thymosin alpha-1 is not TB-500.
- Different research question: An ICU trial does not establish fewer colds or better performance in healthy people.
- Different attribution: Its inclusion here is background context, not confirmation of Rogan’s current use.
What About Melanotan II?
Melanotan II appeared in the earlier version of this guide, but the video sources provided here do not establish that Rogan uses it.
A phase I pilot involving three men found tanning activity and reported effects including nausea, fatigue, and spontaneous erections. That small study does not establish long-term safety.12
It should not be described as part of Rogan’s stack without a clear source identifying it.
🎥 RFK Jr., Brigham Buhler, and Peptide Access
The JRE #2461 conversation with Robert F. Kennedy Jr. addresses the policy discussion around peptides:
When listening, distinguish:
- A speaker’s intended policy change.
- An advisory committee’s recommendation.
- A final agency action and its effective date.
- Approval of a finished drug for a particular use.
The JRE #2469 conversation with Brigham Buhler offers another perspective on access and compounding:
The FDA’s July 2026 advisory-committee agenda included consideration of BPC-157, TB-500, and other substances for the 503A Bulks List. Consideration for compounding is a different question from approval of a finished drug.13
The FDA explicitly states that compounded drugs are not FDA-approved and are not reviewed for safety, effectiveness, or quality before marketing in the same way as approved products.14
Practical interpretation: A podcast prediction should not be used as today’s prescribing or purchasing rule. Check the exact substance, formulation, and current regulatory pathway with the treating clinician or pharmacist.
Peptides vs TRT: What Is the Difference?
Rogan also discusses testosterone replacement in this TRT video. Testosterone is a steroid hormone, not a peptide.
| Category | Main distinction | What to avoid assuming |
|---|---|---|
| BPC-157/TB-500 | Investigated for repair-related effects. | That they replace testosterone treatment. |
| Ipamorelin/CJC-1295 | Act on growth-hormone-related signaling. | That higher GH proves improved performance. |
| TRT | Supplies testosterone for appropriately diagnosed deficiency. | That age or fatigue alone establishes a need. |
Endocrine Society guidance calls for compatible symptoms and consistently low testosterone, with repeat morning testing and evaluation of the cause. Treatment also requires monitoring and consideration of fertility.15
In TRAVERSE, testosterone was noninferior to placebo for major cardiovascular events in men with hypogonadism and cardiovascular disease or elevated risk. Higher rates of atrial fibrillation, acute kidney injury, and pulmonary embolism were observed with testosterone. These results do not make every regimen risk-free.16
Where Does Joe Rogan Buy His Peptides?
The linked sources do not establish his supplier. We would not infer a company from a product photo, affiliate link, or a guest’s business connections.
Our top choice, and one that we’ve been using for quite sometime, is a company called Bioinfinity. You can learn more about them on their website here: www.Bioinfinity.co
Online availability does not make a research product an approved over-the-counter medicine. Supplier information should be evaluated separately from claims about clinical benefits.
Safety Questions to Take Beyond the Podcast
The FDA has published concerns about several peptides discussed here, including limited human safety information, potential immune reactions, and peptide-related impurities.17
- Identify the exact product: Names, fragments, and formulations matter.
- Identify the goal: An injury, hormone deficiency, and a performance goal are different questions.
- Review medications and medical history: A celebrity’s experience cannot establish personal suitability.
- Check sport rules: Testing obligations apply independently of online availability.
WADA prohibits BPC-157 under S0 and lists thymosin beta-4 derivatives, CJC-1295, and ipamorelin under S2; these prohibitions apply at all times.18
Frequently Asked Questions
What Peptides Does Joe Rogan Use?
The clips are useful sources for what he has discussed publicly. They do not establish a complete, current prescription list. This guide therefore separates recovery conversations from related background on other compounds.
What Is Joe Rogan’s Wolverine Stack?
The nickname usually refers to BPC-157 plus TB-500. The pairing is discussed in recovery circles, but its popularity does not establish a standardized dose or guaranteed healing time.
Does Joe Rogan Recommend Bioinfinity?
The sources linked here do not establish that endorsement. Bioinfinity links on this page reflect our own affiliate relationship and supplier preference.
Are Peptides Safer Than TRT?
There is no useful blanket comparison. The answer depends on the substance, indication, formulation, and patient. Limited safety research should not be mistaken for evidence of fewer risks.
Can You Copy a Dose Mentioned on a Podcast?
A personal account does not provide the examination, diagnosis, product verification, or monitoring needed for a treatment decision. This article is an episode and research guide rather than a dosing protocol.
Conclusion
The best way to understand Joe Rogan’s peptide discussions is to keep the videos and the evidence side by side. Watch the original conversation, identify the exact compound, and check whether the supporting research answers the same question.
Personal experiences explain the interest. Human studies, product identity, and clinical assessment determine how far those experiences can reasonably be generalized.
References
- Vasireddi N, Hahamyan H, Salata MJ, et al. Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review. HSS J. 2025;21(4):485-495. doi:10.1177/15563316251355551. PubMed. ↩
- Chang CH, Tsai WC, Lin MS, Hsu YH, Pang JH. The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration. J Appl Physiol (1985). 2011;110(3):774-780. doi:10.1152/japplphysiol.00945.2010. PubMed. ↩
- Hsieh MJ, Liu HT, Wang CN, et al. Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation. J Mol Med (Berl). 2017;95(3):323-333. doi:10.1007/s00109-016-1488-y. PubMed. ↩
- Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P. Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential. Drug Test Anal. 2012;4(9):733-738. doi:10.1002/dta.1402. PubMed. ↩
- Philp D, Badamchian M, Scheremeta B, Nguyen M, Goldstein AL, Kleinman HK. Thymosin beta 4 and a synthetic peptide containing its actin-binding domain promote dermal wound repair in db/db diabetic mice and in aged mice. Wound Repair Regen. 2003;11(1):19-24. doi:10.1046/j.1524-475x.2003.11105.x. PubMed. ↩
- Rahaman KA, Muresan AR, Min H, et al. Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro. J Chromatogr B Analyt Technol Biomed Life Sci. 2024;1235:124033. doi:10.1016/j.jchromb.2024.124033. PubMed. ↩
- Biçer O, Adanir O, Güleryüz Y, et al. Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study. Jt Dis Relat Surg. 2026;37(3):822-837. doi:10.52312/jdrs.2026.2951. PubMed. ↩
- National Cancer Institute. Ipamorelin. NCI Drug Dictionary. Accessed September 12, 2026. Source. ↩
- Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. doi:10.1210/jc.2005-1536. PubMed. ↩
- Alba M, Fintini D, Sagazio A, et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-4. doi:10.1152/ajpendo.00201.2006. PubMed. ↩
- Wu J, Pei F, Zhou L, et al. The efficacy and safety of thymosin α1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial. BMJ. 2025;388:e082583. doi:10.1136/bmj-2024-082583. PubMed. ↩
- Dorr RT, Lines R, Levine N, et al. Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study. Life Sci. 1996;58(20):1777-1784. doi:10.1016/0024-3205(96)00160-9. PubMed. ↩
- US Food and Drug Administration. July 23–24, 2026: Meeting of the Pharmacy Compounding Advisory Committee. Accessed September 12, 2026. Source. ↩
- US Food and Drug Administration. Understanding the risks of compounded drugs. Accessed September 12, 2026. Source. ↩
- Bhasin S, Brito JP, Cunningham GR, et al. Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(5):1715-1744. doi:10.1210/jc.2018-00229. PubMed. ↩
- Lincoff AM, Bhasin S, Flevaris P, et al. Cardiovascular Safety of Testosterone-Replacement Therapy. N Engl J Med. 2023;389(2):107-117. doi:10.1056/nejmoa2215025. PubMed. ↩
- US Food and Drug Administration. Certain bulk drug substances for use in compounding that may present significant safety risks. Accessed September 12, 2026. Source. ↩
- World Anti-Doping Agency. The Prohibited List. Accessed September 12, 2026. Source. ↩
